Cirroc Lofton played the regular role of Jake Sisko on Star Trek: Deep Space Nine beginning in 1993. Although he watched the original Star Trek series and was a fan, Lofton prefers The Twilight Zone.  He made his first acting appearance in the 1992 hit film Beethoven.  He was cast as Jake Sisko later that year.  Filming DS9 kept him busy, but he made his first guest appearance in an 1996 episode of Moesha.  He later made two guest appearances in Smart Guy as two different characters.  Soon after DS9 ended, he was a main cast member on The Hoop Life.

Two years after DS9 ended, he guest-starred as Anthony Carter in the Soul Food episodes "Nice Work if You Can Get It" and "Come Back for the Comeback."  The former episode was directed by LeVar Burton and starred James Avery as a relation of Lofton's character.  Vanessa Williams was a regular on this series.

In 2003 he guest-starred in 7th Heaven, starring Star Trek film actors Catherine Hicks and Stephen Collins.  In 2006, he appeared in the TV series Invasion alongside fellow DS9 star Armin Shimerman and Voyager guest star Ivar Brogger.  The following year, he made an appearance on CSI: Miami.

In 2004, he appeared in Trekkies 2 and in the motion picture Fronterz.  He recently completed work on the independent feature The Inevitable Undoing of Jay Brooks, starring Star Trek: Enterprise's Anthony Montgomery in the title role.